Authors

Wijdan Abdulghani Saleh

Department of Biology, College of Science, University of Kirkuk, Iraq

Afaf Saud Hussein

Department of Biology, College of Science, University of Kirkuk, Iraq

Donia Suad Shakoor

Department of Biology, College of Science, University of Kirkuk, Iraq

Parzhin Sardar Mohammed

Department of Biology, College of Science, University of Kirkuk, Iraq

Abstract

This study was meant to investigate the mechanistic factors behind HEV infection causing severe clinical disease in pregnancy, targeting immune, hormonal, coagulation, and placental parameters in a case-control design with 77 HEV-infected pregnant women and 77 matched healthy controls in Iraq (January-December 2024 ). Sought were cytokine profiles (IFN-γ, IL-4, IL-10, TNF-α) and immune cell subsets (e.g., regulatory T cells), serum estradiol, progesterone, and cortisol concentrations; coagulation markers (PT, aPTT, D-dimer, fibrinogen). Laboratory investigations included ELISA kits for anti-HEV IgM/IgG; qualitative real-time PCR; multiplex cytokine assays; flow cytometry; hormone ELISAs; coagulation panels on an automated analyser.

Significant differences were observed in HEV-infected pregnant women who had developed a Th2 essentially regulatory immune profile, evidenced by noticeably lower IFN-γ and higher IL-4, IL-10, TNF-α, and Treg cell percentages versus controls (p

Keywords

HEV infection Pregnant Women Pathogenic Mechanisms Elevated Maternal Mortality Risk targeting immune hormonal coagulation placental parameters

Citation of this Article

Wijdan Abdulghani Saleh, Afaf Saud Hussein, Donia Suad Shakoor, & Parzhin Sardar Mohammed. (2025). Physiological Dysregulations Associated with Hepatitis E Virus Infection in Pregnant Women: An Analytical Study of Pathogenic Mechanisms and Elevated Maternal Mortality Risk. Current Journal of Engineering and Science Research. 2(8), 6-12. Article DOI: https://doi.org/10.47001/CJESR/2025.208002

Licence Copyright (c) 2026 Current Journal of Engineering and Science Research. This work is licensed under a Creative Commons Attribution Non Commercial 4.0 International Licence.

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